Publicaciones

2022

Implication of Type 4 NADPH Oxidase (NOX4) in Tauopathy. Redox Biology. Feb 2022. DOI: 10.1016/j.redox.2021.102210

2021

Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals. Molecules. Apr. 2021. DOI: 10.3390/molecules26082107

Protective role of microglial HO-1 blockade in aging: implication of iron metabolism. Redox Biology. Jan 2021. DOI: 10.1016/j.redox.2020.101789.

2020

Cognitive enhancement, tau phosphorylation reduction and neuronal protection by the treatment of a LRRK2 inhibitor in a taoupathy mouse model.  Neurobiology of Aging. Dec 2020. DOI: 10.1016/j.neurobiolaging.2020.09.006

Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization. Pharmacological Research. Feb 2020. DOI: 10.1016/j.phrs.2019.104597

Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties. Eur. J. Med. Chem. Mar 2020. DOI: 10.1016/j.ejmech.2020.112090

Optical control of muscular nicotinic channels with azocuroniums, photoswitchable azobenzenes bearing two N-methyl-N-carbocyclic quaternary ammonium groups. Eur. J. Med. Chem. May 2020. DOI: 10.1016/j.ejmech.2020.112403

Aza-CGP37157-lipoic hybrids designed as novel Nrf2-inducers and antioxidants exert neuroprotection against oxidative stress and show neuroinflammation inhibitory properties. Drug Development Research. May 2020. DOI: 10.1002/ddr.21618

NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases. Biomolecules. Jun 2020. DOI: 10.3390/biom10060904

Aging and Progression of Beta-Amyloid Pathology in Alzheimer’s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression. Antioxidants. Jul 2020. DOI: 10.3390/antiox9070644

Na+ controls hypoxic signalling by the mitochondrial respiratory chain. Nature. Jul 2020. DOI 10.1038/s41586-020-2551-y.

When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration. Antioxidants. Aug 2020. DOI: 10.3390/antiox9080740 

Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism. Redox Biology. Nov 2020. DOI: 10.1016/j.redox.2020.101789

Perspectives on the Clinical Development of NRF2-Targeting Drugs. Handbook of Experimental Pharmacology (Chapter). Aug 2020. DOI: 10.1007/164_2020_381

2019

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nat Rev Drug Discov. Jan 2019. DOI: 10.1038/s41573-018-0008-

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties. J. Enzyme Inhib. Med. Chem. Mar 2019. DOI: 10.1080/14756366.2019.1581184  

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development. Oxid Med Cell Longev. Jul 2019. DOI: 10.1155/2019/9372182

2018

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy. Redox Biol. Apr 2018. DOI: 10.1016/j.redox.2017.10.010.

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach. Pharmacol Rev. April 2018. DOI:10.1124/pr.117.014753

Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy. Jul 2018. DOI: 10.1080/15548627.2018.1474992

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy. Redox Biol. Sep 2018. DOI: 10.1016/j.redox.2018.07.006

Multi-target-directed ligands for Alzheimer´s disease: discovery of chromone-based monoamine oxidase/cholinesterase inhibitors. Eur. J. Med. Chem. Oct 2018. DOI: 10.1016/j.ejmech.2018.07.056