Publications
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Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nat Commun. 2021
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Cannabinoid receptor CB2 ablation protects against tau induced neurodegeneration. Acta Neuropathologica Communications. 2021.
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Guidelines for the use and Interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021.
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Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals. Molecules 2021.
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Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization. Pharmacol Res. 2020.
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Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: discovery of QR2 ligands and NRF2 activators with neurogenic properties. Eur. J. Med. Chem. 2020.
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Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathy. bioRxiv. 2020.
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Antioxidant, anti-inflammatory and neuroprotective profiles of novel 1,4-dihydropyridine derivatives for the treatment of Alzheimer’s disease. Antioxidants. 2020
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Molecular and pharmacological modulation of CALHM1 promotes neuroprotection against oxygen and glucose deprivation in a model of hippocampal slices. Cells. 2020.
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Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models once tauopathy is initiated, by restoring the autophagic flux. J Pineal Res. 2019.
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Na+ controls hypoxic signalling by the mitochondrial respiratory chain. Nature. 2020.
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Cognitive enhancement, tau phosphorylation reduction and neuronal protection by the treatment of a LRRK2 inhibitor in a tauopathy mouse model. Neurobiology of Aging. 2020.
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Calcium-dependent reactive oxygen formation and blood-brain barrier breakdown by NOX5 limits post-reperfusion benefit in stroke. J Clin. Invest. 2019.
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From single drug targets to synergistic network pharmacology in ischemic stroke. PNAS. 2019.
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Neuroprotective effects of EpoL against oxidative stress induced by soluble oligomers of Aß peptide. Redox Biol. 2019.
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Improvement in inflammation is associated with the protective effect of Gly-Pro-Glu and cycloprolylglycine against Aβ-induced depletion of the hippocampal somatostatinergic system. Neuropharmacology. 2019.
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Melatonin treatment impedes cognitive decline in tau-related Alzheimer models once tauopathy is initiated, by restoring the autophagic flux. J. Pineal Res. 2019.
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Neuroprotective activity of isoquinoline alkaloids from of Chilean Amaryllidaceae plants against oxidative stress-induced cytotoxicity on human neuroblastoma SH-SY5Y cells and mouse hippocampal slice culture. Food and Chemical Toxicology. 2019.
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Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy. Redox Biol. 2018.
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Heme-oxygenase I and PCG-1α regulate mitochondrial biogenesis via microglial activation of alpha7 nicotinic acetylcholine receptors using PNU282987. Antioxidants & Redox Signaling. 2017.
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