Publicaciones

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nat Commun. 2021

Cannabinoid receptor CB2 ablation protects against tau induced neurodegeneration. Acta Neuropathologica Communications. 2021.

Guidelines for the use and Interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021.

Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals. Molecules 2021.

Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization. Pharmacol Res. 2020.

Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: discovery of QR2 ligands and NRF2 activators with neurogenic properties. Eur. J. Med. Chem. 2020.

Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathy. bioRxiv. 2020.

Antioxidant, anti-inflammatory and neuroprotective profiles of novel 1,4-dihydropyridine derivatives for the treatment of Alzheimer’s disease. Antioxidants. 2020

Molecular and pharmacological modulation of CALHM1 promotes neuroprotection against oxygen and glucose deprivation in a model of hippocampal slices. Cells. 2020.

Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models once tauopathy is initiated, by restoring the autophagic flux. J Pineal Res. 2019.

Na+ controls hypoxic signalling by the mitochondrial respiratory chain. Nature. 2020.

Cognitive enhancement, tau phosphorylation reduction and neuronal protection by the treatment of a LRRK2 inhibitor in a tauopathy mouse model. Neurobiology of Aging. 2020.

Calcium-dependent reactive oxygen formation and blood-brain barrier breakdown by NOX5 limits post-reperfusion benefit in stroke. J Clin. Invest. 2019.

From single drug targets to synergistic network pharmacology in ischemic stroke. PNAS. 2019.

Neuroprotective effects of EpoL against oxidative stress induced by soluble oligomers of Aß peptide. Redox Biol. 2019.

Improvement in inflammation is associated with the protective effect of Gly-Pro-Glu and cycloprolylglycine against Aβ-induced depletion of the hippocampal somatostatinergic system. Neuropharmacology. 2019.

Melatonin treatment impedes cognitive decline in tau-related Alzheimer models once tauopathy is initiated, by restoring the autophagic flux. J. Pineal Res. 2019.

Neuroprotective activity of isoquinoline alkaloids from of Chilean Amaryllidaceae plants against oxidative stress-induced cytotoxicity on human neuroblastoma SH-SY5Y cells and mouse hippocampal slice culture. Food and Chemical Toxicology. 2019.

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy. Redox Biol. 2018.

Heme-oxygenase I and PCG-1α regulate mitochondrial biogenesis via microglial activation of alpha7 nicotinic acetylcholine receptors using PNU282987. Antioxidants & Redox Signaling. 2017.

Novel sulfoglycolipid IG20 causes neuroprotection by activating the phase II antioxidant response in rat hippocampal slices. Neuropharmacology. 2017.